top of page
Untitled-1.jpf

Our research

We seek to understand how cells protect and destroy mRNAs, lncRNAs, and different classes of small RNAs. Our lab applies genetics, biochemistry, high-throughput sequencing, and computational modeling to define the biological roles of RNA metabolism in development and disease.

Publications

Relaxed targeting rules help PIWI proteins silence transposons.

Gainetdinov I, Vega-Badillo J, Cecchini K, Bagci A, Colpan C, De D, Bailey S, Arif A, Wu PH, MacRae IJ, Zamore PD.

Nature. 2023; 619: 394–402.

Terminal modification, sequence, length, and PIWI-protein identity determine piRNA stability.

Gainetdinov I, Colpan C, Cecchini K, Arif A, Jouravleva K, Albosta P, Vega-Badillo J, Lee Y, Özata DM, Zamore PD.

Mol Cell. 2021; 81: 4826–4842.

A Single Mechanism of Biogenesis, Initiated and Directed by PIWI Proteins, Explains piRNA Production in Most Animals.

Gainetdinov I*, Colpan C*, Arif A, Cecchini K, Zamore PD. *co-first authors
Mol Cell. 2018; 71: 775-790.

A maternally programmed intergenerational mechanism enables male offspring to make piRNAs from Y-linked precursor RNAs in Drosophila.

Venkei ZG*, Gainetdinov I*, Bagci A, Starostik MR, Choi CP, Fingerhut JM, Chen P, Balsara C, Whitfield TW, Bell GW, Feng S, Jacobsen SE, Aravin AA, Kim JK, Zamore PD, Yamashita YM. *co-first authors

Nat Cell Biol 2023; doi.org/10.1038/s41556-023-01227-4

bottom of page